Adverse Effects of Analgesics Commonly Used by Older Adults With Osteoarthritis: Focus on Non-Opioid and Opioid Analgesics

Non-opioid analgesics

C describe the concept of multimodal analgesia and give examples Abstract Opium is the natural substance to which modern narcotics owe their existence. First discovered in the 1500s, opium was the most potent analgesic compound in use, held in high regard, hence its Latin name laudanum (to praise). Subsequent studies into the effects of opium led to the discovery of the opioid receptors, and th...

Opioid Analgesics

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...

Opioid and Nonopioid Analgesics

NON OPIOID ANALGESICS and ANTI-INFLAMMATORY MEDICATIONS

Paracetamol has analgesic and antipyretic e ects that are similar to aspirin, but little or no antiin ammatory activity. It is generally accepted that it has little e ect on extracerebral COX-1 or COX-2, although it inhibits central COX-3. Consequently, it prevents the enhanced synthesis of prostaglandin E2 in the hypothalamus during pyrexia, and thus reduces elevated body temperature. It has s...

Pain Pharmacotherapy: Non-Opioid Analgesics [Argoff]

Links: [1] https://www.opioidrisk.com/node/142 [2] http://aps.confex.com/aps/res2008/webprogram/Session2442.html [3] https://www.opioidrisk.com/taxonomy/term/517 [4] https://www.opioidrisk.com/taxonomy/term/554 [5] https://www.opioidrisk.com/taxonomy/term/548 [6] https://www.opioidrisk.com/taxonomy/term/491 [7] https://www.opioidrisk.com/taxonomy/term/179 [8] https://www.opioidrisk.com/taxonomy...